Potato is the fourth largest food crop in the world and also a major food crop in China.It plays a signi-ficant role in ensuring food security.With global warming,drought has become a frequent natural disaster in agricultural production,seriously restricting potato production.The mechanism of drought resistance in potato was reviewed from the aspects of signal transduction,transcription factors and osmotic regulation,and the approaches and measures to improve drought resistance in potato were discussed from the aspects of the development of multi-omics.Furthermore,the research direction and methods of potato drought tolerance were prospected.This review would provide reference for further study of potato drought resistance mechanism and breeding of improved varieties.