Clinical Efficacy and Safety Analysis of Photodynamic Therapy Combined with Oral Isotretinoin in the Treatment of Moderate to Severe Acne
Objective To investigate the clinical efficacy and safety of photodynamic therapy combined with oral isotretinoin in the treatment of moderate to severe acne.Methods From June 2020 to June 2022,84 patients with moderate to severe acne admitted to the author's hospital were randomly divided into isotretinoin group,phototherapy group,and combined treatment group,with 28 patients in each group.The isotretinoin group was treated with oral isotretinoic,the phototherapy group was treated with photodynamic therapy,and the combined treatment group was treated with photodynamic therapy combined with oral isotretinoic.The treatment effect was evaluated,and the number of skin lesions and quality of life of patients before and after 8 weeks of treatment were observed.The adverse reactions during treatment were recorded.Results The total effective rate of 82.14%in the combined treatment group was significantly higher than 46.43%in the isotretinoin group and 57.14%in the phototherapy group(all P＜0.05).After treatment,the non inflammatory skin lesions in the combined treatment group were significantly lower than those in the isotretinoin group and the phototherapy group(P＜0.05),while the inflammatory skin lesions in the combined treatment group and the phototherapy group were significantly lower than those in the isotretinoin group(P＜0.05).After treatment,the Acne-Qol scores in all dimensions of patients in the three groups were significantly higher than before treatment(P＜0.05),and the combined treatment group was significantly higher than the isotretinoin group and the phototherapy group(P＜0.05).The incidence of erythema edema,reactive acne,and pigmentation in the combined treatment group and the phototherapy group were higher than those in the isotretinoin group(P＜0.05).There was no statistically significant difference in dry desquamation among the three groups(P＞0.05).Conclusion Photodynamic therapy combined with oral isotretinoin in the treatment of moderate to severe acne can effectively improve the clinical efficacy,significantly improve the condition of skin lesions and quality of life of patients.
isotretinoicphotodynamic therapymoderate to severe acneclinical efficacysafetyquality of life
万方数据
维普
