Skin atrophy is one of the most prevalent side-effects of topical glucocorticosteroids.The mechanisms involved in topical glucocorticoids-induced skin atrophy include suppressing keratinocyte proliferation,accelerating their maturation,inhibiting the synthesis of epidermal lipids,suppressing fibroblast proliferation,reducing the synthesis of extracellular matrix such as collagen and hyaluronic acid,etc.In recent years,the research on the prevention and treatment of this side-effect mainly focuses on the development of selective modulators of glucocorticoid receptor,targeted inhibition of atrophogenes and related signal pathways,combination with other nuclear receptor agonists.
维普
万方数据