Objective To analyze the effect of microparticle fat injection on the width and aesthetics of lacrimal groove in patients after lower eyelid plasty.Methods A total of 80 patients with lacrimal trough deformity who were treated in the author's hospital from January 2022 to November 2022 were selected as the research subjects and divided into 40 cases(62 eyes)of the control group and 40 cases(59 eyes)of the research group according to the random number table.Patients in the control group received standard lower eyelid plasty,while patients in the study group collected the fat of the infraorbital septum during the operation.After lower eyelid plasty,the percutaneous microparticle fat was injected into the infraorbital groove.The postoperative conditions,aesthetic satisfaction and postoperative complications of the two groups were compared.Results There was no significant difference in healing condition or follow-up time between the two groups(P>0.05).The distance from pupil to eyelid,the distance from pupil to lacrimal groove and the width of lacrimal groove in patients of the study group were significantly improved than those of the control group,and the tear groove deformity rating scale(TTRS)score was lower than that of the control group(P<0.05).After 3 months,the aesthetic satisfaction of the study group was significantly higher than that of the control group(P<0.05).After 3 months,there was no significant difference in the total incidence of complications such as hematoma,ectropion and swelling between the two groups(P>0.05).Conclusion Microparticle fat injection during lower eyelid plasty can safely and effectively overcome lacrimal groove deformity and improve facial aesthetics.