Clinical Observation of Calcium Hydroxide,Tinidazole and Concentrated Growth Factor in the Treatment of Pulp Necrosis or Periapical Periodontitis of Young Permanent Teeth
Objective To observe the curative effect of calcium hydroxide and tinidazole combined with concentrated growth factor on pulp necrosis or periapical periodontitis of young permanent teeth.Methods From July 2019 to April 2021,86 young children with permanent tooth pulp necrosis or apical periodontitis diagnosed and treated in author's hospital were grouped into the routine group[n=43,application of calcium hydroxide and tinidazole in root canal disinfection in pulp revascularization(PR)]and concentrated growth factor group(n=43,concentrated growth factor was added on the basis of routine group)according to the random number table method.At 12 months after the operation,the curative effect of the two groups was judged,and the wall thickness,root length,masticatory efficiency[bite force,masticatory efficiency]and the deposition rate of cementum-like tissue were compared between the two groups.Results The total effective rate was 95.35%in the concentrated growth factor group and 81.40%in the routine group,there was a obvious difference between the groups(P＜0.05);at 12 months after operation,the root canal wall in both groups was thicker than that before operation(P＜0.05),the root length was obviously increased(P＜0.05),and the occlusal force and chewing efficiency were obviously higher than those before operation(P＜0.05),and the root canal wall in the concentrated growth factor group was obviously thicker than that in the conventional group(P＜0.05),the root length was obviously longer than that in the conventional group(P＜0.05),and the occlusal force and chewing efficiency were obviously higher than those in the conventional group(P＜0.05).The deposition rates of cementoid tissue at 6 and 12 months in the concentrated growth factor group were obviously higher than those in the conventional group(P＜0.05).Conclusion The combination of calcium hydroxide and tinidazole concentration of growth factor in PR of patients with pulp necrosis or periapical inflammation can significantly improve the deposition rate of bone tissue,effectively promote the growth of root canal and functional recovery of affected teeth.
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