Keloid is a benign tumor common in dermatology that causes an overgrowth of connective tissue of the skin.MicroRNA(microRNA,miRNA)is a class of non-coding single-stranded RNA molecules,mainly involved in the regulation of protein expression after transcription of biological genes and the pathophysiological processes of various diseases.At present,differential expression of miRNA has been found to be associated with the growth and invasion of keloid fibroblasts,the accumulation of extracellular matrix collagen,and angiogenesis.This article will describe the research progress of miRNA in keloids,and provide new ideas for the diagnosis and treatment of keloids.