Effect of Supramolecular Salicylic Acid on p38MAPK/NF-κB Signaling Pathway in Rabbit Ear Acne Models
Objective To explore the effect of supramolecular salicylic acid on p38MAPK/NF-κB signaling pathway in rabbit ear acne model.Methods Divided thirty experimental rabbits into normal control group,2%SA group,30%SA group,fusidic acid group and model control group(There were 6 rabbits in each group)randomly.Gave corresponding external drug intervention for 4 weeks.Detected the expressions of p38MAPK,NF-κB,IL-1β and IL-8 after 2 weeks and 4 weeks.Results Result display,P38MAPK,NF-κB,IL-1β,and IL-8 of each group showed a downward trend after treatment.Before treatment,there were no significant differences in expression of p38MAPK,NF-κB,IL-1β and IL-8 among groups(P＞0.05).After 2 weeks of treatment,p38MAPK,NF-κB,IL-1β,and IL-8 of 2%SA group,30%SA group and fusidic acid group were lower than model control group(P＜0.001).There were no significant differences in p38MAPK,NF-κB,and IL-1β(P＞0.05).IL-8 of 2%SA group was lower than 30%SA group and fusidic acid group(all P＜0.05).There was no significant difference in IL-8 between 30%SA group and fusidic acid group(P＞0.05).After 4 weeks of treatment,p38MAPK,NF-κB,IL-1β,and IL-8 of three treatment groups were lower than model control group(P＜0.05).p38MAPK,NF-κB,IL-8 of 2%SA group and 30%SA group was lower than fusidic acid group(P＜0.05),IL-8 of 2%SA group was lower than 30%SA group(P＜0.05).There was no significant difference in p38MAPK between 2%SA group and 30%SA group(P＞0.05).2%SA group,30%SA group and fusidic acid group had no significant difference in IL-1β(all P＞0.05).2%SA group IL-1β was lower than 30%SA group,the difference was Statistical significance(P＜0.05).Conclusion Supramolecular salicylic acid can exert an anti-inflammatory effect by inhibiting the p38MAPK/NF-κB signaling pathway,and the curative effect gradually increases with the prolongation of medication time,and is superior to fusidic acid.
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