女性型脱发患者的血清维生素D水平及与雄激素的相关性研究
Serum Vitamin D Level in Female Pattern Hair Loss Patients and Relationship with Androgen
陈宇凌 1白杨娟 2王奕欣 1董薪 1李利1
作者信息
- 1. 四川大学华西医院皮肤科 四川 成都 610041
- 2. 四川大学华西医院实验医学科 四川 成都 610041
- 折叠
摘要
目的:探究女性型脱发的血清维生素D水平以及与雄激素的相关性,为女性型脱发的发病机制及治疗选择提供新的线索.方法:分析皮肤科门诊就诊的70例女性型脱发患者与体检中心招募的65例健康人的血清维生素D,分析其与严重程度、人口学特征、生活习惯以及雄激素的相关性.结果:女性型脱发患者的平均维生素D水平(13.59±5.82)ng/ml,健康人群的平均维生素D水平为(15.94±6.89)ng/ml(P＜0.05).女性型脱发患者维生素D水平与性激素结合球蛋白呈正相关,与游离睾酮呈负相关(P＜0.05).性激素结合球蛋白降低或游离睾酮升高的患者维生素D水平明显降低(P＜0.05).但暂未发现女性型脱发患者的维生素D水平与严重程度、人口学特征、生活习惯的相关性.结论:女性型脱发较健康人群维生素D水平明显降低,提示维生素D降低可能是女性型脱发的发病因素之一.性激素结合球蛋白降低、游离睾酮升高与维生素D水平降低存在的相关性,可能是维生素D缺乏导致女性型脱发的机制之一,有待进一步研究验证.
Abstract
Objective To explore the relationship between serum vitamin D levels and androgen levels in female pattern hair loss(FPHL),and to provide new clues for the pathogenesis and treatment of FPHL.Methods We analyzed serum vitamin D levels in 70 patients with female pattern alopecia and 65 healthy subjects recruited from hospital and physical examination center.We also analyzed the relationship between serum vitamin D levels and disease severity,demographic characteristics,lifestyle habits,and androgens.Results The mean levels of serum vitamin D significantly decreased in FPHL,compared to those healthy controls[(13.59±5.82)ng/ml vs(15.94±6.89)ng/ml].There was a positive correlation between vitamin D and sex hormone binding globulin(SHBG)(P＜0.05),and a negative correlation between vitamin D and free testosterone(P＜0.05).Serum vitamin D levels was significantly lower in those patients with decrease SHBG or elevated free testosterone.However,no correlation was found between vitamin D level and severity,demographic characteristics,and lifestyle in FPHL.Conclusion The vitamin D level of FPHL is significantly lower than that of healthy people,suggesting that the decrease of vitamin D may be one of the pathogenesis factors of FPHL.The correlation between SHBG,free testosterone and vitamin D may be the reason of the vitamin D deficiency in FPHL,which needs more studies to verify.Serum vitamin D,SHBG and free testosterone should be monitored more actively in FPHL patients.
关键词
女性型脱发/维生素D/雄激素/性激素结合球蛋白/游离睾酮Key words
female pattern hair loss/vitamin D/androgen/sex hormone binding globulin/free testosterone引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据