首页|女性型脱发患者的血清维生素D水平及与雄激素的相关性研究

女性型脱发患者的血清维生素D水平及与雄激素的相关性研究

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目的:探究女性型脱发的血清维生素D水平以及与雄激素的相关性,为女性型脱发的发病机制及治疗选择提供新的线索.方法:分析皮肤科门诊就诊的70例女性型脱发患者与体检中心招募的65例健康人的血清维生素D,分析其与严重程度、人口学特征、生活习惯以及雄激素的相关性.结果:女性型脱发患者的平均维生素D水平(13.59±5.82)ng/ml,健康人群的平均维生素D水平为(15.94±6.89)ng/ml(P<0.05).女性型脱发患者维生素D水平与性激素结合球蛋白呈正相关,与游离睾酮呈负相关(P<0.05).性激素结合球蛋白降低或游离睾酮升高的患者维生素D水平明显降低(P<0.05).但暂未发现女性型脱发患者的维生素D水平与严重程度、人口学特征、生活习惯的相关性.结论:女性型脱发较健康人群维生素D水平明显降低,提示维生素D降低可能是女性型脱发的发病因素之一.性激素结合球蛋白降低、游离睾酮升高与维生素D水平降低存在的相关性,可能是维生素D缺乏导致女性型脱发的机制之一,有待进一步研究验证.
Serum Vitamin D Level in Female Pattern Hair Loss Patients and Relationship with Androgen
Objective To explore the relationship between serum vitamin D levels and androgen levels in female pattern hair loss(FPHL),and to provide new clues for the pathogenesis and treatment of FPHL.Methods We analyzed serum vitamin D levels in 70 patients with female pattern alopecia and 65 healthy subjects recruited from hospital and physical examination center.We also analyzed the relationship between serum vitamin D levels and disease severity,demographic characteristics,lifestyle habits,and androgens.Results The mean levels of serum vitamin D significantly decreased in FPHL,compared to those healthy controls[(13.59±5.82)ng/ml vs(15.94±6.89)ng/ml].There was a positive correlation between vitamin D and sex hormone binding globulin(SHBG)(P<0.05),and a negative correlation between vitamin D and free testosterone(P<0.05).Serum vitamin D levels was significantly lower in those patients with decrease SHBG or elevated free testosterone.However,no correlation was found between vitamin D level and severity,demographic characteristics,and lifestyle in FPHL.Conclusion The vitamin D level of FPHL is significantly lower than that of healthy people,suggesting that the decrease of vitamin D may be one of the pathogenesis factors of FPHL.The correlation between SHBG,free testosterone and vitamin D may be the reason of the vitamin D deficiency in FPHL,which needs more studies to verify.Serum vitamin D,SHBG and free testosterone should be monitored more actively in FPHL patients.

female pattern hair lossvitamin Dandrogensex hormone binding globulinfree testosterone

陈宇凌、白杨娟、王奕欣、董薪、李利

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四川大学华西医院皮肤科 四川 成都 610041

四川大学华西医院实验医学科 四川 成都 610041

女性型脱发 维生素D 雄激素 性激素结合球蛋白 游离睾酮

国家自然科学基金

82173441

2024

中国美容医学
西安交通大学第四军医大学

中国美容医学

CSTPCD
影响因子:1.006
ISSN:1008-6455
年,卷(期):2024.33(3)
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