ⅩⅦ型胶原蛋白在脱发中的作用机制研究进展
Research Progress on the Mechanism of Collagen Type ⅩⅦ in Alopecia
郑屿萍 1黄清瑞 1张彦峰 1张慧敏 1何翔1
作者信息
- 1. 上海中医药大学附属曙光医院皮肤科 上海 201203
- 折叠
摘要
脱发是一种较为常见的皮肤疾病,其发病率逐年上升,并呈年轻化趋势发展,困扰着越来越多人的生活,以进行性毛囊微型化、毛发生长期缩短为特点,导致毛发附着松散容易脱落.ⅩⅦ型胶原蛋白是一种跨膜蛋白,位于表皮基底膜区的半桥粒,维持表皮真皮之间的紧密连接.近期研究发现,ⅩⅦ型胶原蛋白参与毛发生长,调节毛发相关细胞的静息与活化.若缺失ⅩⅦ型胶原蛋白可通过DNA损伤效应累积、表皮细胞极性失衡以及抑制干细胞竞争导致脱发.本文将对ⅩⅦ型胶原蛋白在脱发中的作用机制予以综述,为毛发再生领域研究提供方向.
Abstract
Alopecia is a common skin disease.Its incidence is increasing year by year,and it is developing in a younger trend,which is plaguing more and more people's lives.It is characterized by progressive hair follicle miniaturization and shortening of hair growth period,resulting in loose hair attachment and easy shedding.Collagen type ⅩⅦ is a transmembrane protein located in the hemidesmosomes of the epidermal basement membrane zone,maintaining the tight junction between epidermis and dermis.Recent studies have found that collagen type ⅩⅦ is involved in hair growth and can regulate the quiescence and activation of hair-related cells.Deletion of collagen type ⅩⅦ can lead to alopecia through accumulation of DNA damage effects,imbalance of epidermal cell polarity and inhibition of stem cell competition.This article will review the mechanism ofⅩⅦ collagen in alopecia and provide a direction for the field of hair regeneration.
关键词
ⅩⅦ型胶原蛋白/毛囊/干细胞/衰老/脱发/再生Key words
collagen type ⅩⅦ/hair follicle/stem cells/senescence/alopecia/regeneration引用本文复制引用
基金项目
国家自然科学基金项目(81974570)
上海市自然科学基金(21ZR1464000)
上海市科学技术委员会启明星(扬帆专项)(22YF1449500)
出版年
2024
国家科技期刊平台
NSTL
万方数据