首页|ⅩⅦ型胶原蛋白在脱发中的作用机制研究进展

ⅩⅦ型胶原蛋白在脱发中的作用机制研究进展

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脱发是一种较为常见的皮肤疾病,其发病率逐年上升,并呈年轻化趋势发展,困扰着越来越多人的生活,以进行性毛囊微型化、毛发生长期缩短为特点,导致毛发附着松散容易脱落.ⅩⅦ型胶原蛋白是一种跨膜蛋白,位于表皮基底膜区的半桥粒,维持表皮真皮之间的紧密连接.近期研究发现,ⅩⅦ型胶原蛋白参与毛发生长,调节毛发相关细胞的静息与活化.若缺失ⅩⅦ型胶原蛋白可通过DNA损伤效应累积、表皮细胞极性失衡以及抑制干细胞竞争导致脱发.本文将对ⅩⅦ型胶原蛋白在脱发中的作用机制予以综述,为毛发再生领域研究提供方向.
Research Progress on the Mechanism of Collagen Type ⅩⅦ in Alopecia
Alopecia is a common skin disease.Its incidence is increasing year by year,and it is developing in a younger trend,which is plaguing more and more people's lives.It is characterized by progressive hair follicle miniaturization and shortening of hair growth period,resulting in loose hair attachment and easy shedding.Collagen type ⅩⅦ is a transmembrane protein located in the hemidesmosomes of the epidermal basement membrane zone,maintaining the tight junction between epidermis and dermis.Recent studies have found that collagen type ⅩⅦ is involved in hair growth and can regulate the quiescence and activation of hair-related cells.Deletion of collagen type ⅩⅦ can lead to alopecia through accumulation of DNA damage effects,imbalance of epidermal cell polarity and inhibition of stem cell competition.This article will review the mechanism ofⅩⅦ collagen in alopecia and provide a direction for the field of hair regeneration.

collagen type ⅩⅦhair folliclestem cellssenescencealopeciaregeneration

郑屿萍、黄清瑞、张彦峰、张慧敏、何翔

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上海中医药大学附属曙光医院皮肤科 上海 201203

ⅩⅦ型胶原蛋白 毛囊 干细胞 衰老 脱发 再生

国家自然科学基金项目上海市自然科学基金上海市科学技术委员会启明星(扬帆专项)

8197457021ZR146400022YF1449500

2024

中国美容医学
西安交通大学第四军医大学

中国美容医学

CSTPCD
影响因子:1.006
ISSN:1008-6455
年,卷(期):2024.33(3)
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