翼状胬肉术后复发风险及其与病情特征的相关性
Risk of Postoperative Recurrence of Pterygium and Its Correlation with Disease Characteristics
盛书华 1赵军民 2姜河1
作者信息
- 1. 合肥市第八人民医院眼科 安徽合肥 238000
- 2. 合肥市第一人民医院眼科 安徽合肥 230000
- 折叠
摘要
目的:探讨翼状胬肉术后复发风险及其与病情特征的相关性.方法:选取2017年3月-2022年3月于笔者医院收治的189例翼状胬肉患者为研究对象,所有患者均接受翼状胬肉切除和自体角膜缘干细胞移植术.收集所有患者一般资料以及病情特征.术后对所有患者进行为期1年的随访.根据术后有无复发分为复发组和未复发组,采用多因素Logistic回归分析影响两组患者复发的相关因素,收集手术切除组织,采用免疫组织化学法检测血管内皮生长因子(Vascular endothelial growth factor,VEGF)水平;采用Pearson相关性分析翼状胬肉相对长度(Relative length,RL)、相对宽度(Relative width,RW)、相对面积(Relative area,RA)、血管指数(Vascularization index,VI)间的相关性.结果:随访结束后共有7例失访病例,最后共计纳入研究病例数为182例.两组性别、合并疾病、吸烟、饮酒,以及家族史比较差异无统计学意义(P＞0.05);两组患者翼状胬肉RL、RW、RA、VI以及血VEGF对比差异具有统计学意义(P＜0.05);多因素Logistic回归结果显示,VEGF[OR=0.695,95％CI(0.568,0.851)]、RL[OR=0.920,95％CI(0.876,0.966)]、RA[OR=0.871,95％CI(0.784,0.969)]以及VI[OR=0.911,95％CI(0.867,0.957)]均是术后翼状胬肉复发的相关因素(P＜0.05).Pearson相关性分析得出RL、RW、RA、VI各指标间呈正相关(P＜0.05).结论:翼状胬肉RL、RW、RA、VI各指标间呈正相关且RL、RW、VI以及VEGF是影响术后翼状胬肉复发的相关因素.
Abstract
Objective To explore the risk of postoperative recurrence of pterygium and its correlation with the characteristics of the disease.Methods From March 2017 to March 2022,189 patients with pterygium in the author's hospital were taken as the research object.All patients underwent pterygium excision and limbal stem cell transplantation.Collect the general information and disease characteristics of all patients.All patients were followed up for one year after operation.According to whether there was recurrence after operation,the patients were divided into recurrence group and non-recurrence group.Multivariate Logistic regression was used to analyze the related factors affecting the recurrence of the two groups.The resected tissues were collected and the vascular endothelial growth factor(VEGF)was detected by immunohistochemical method.Pearson correlation was used to analyze the correlation among relative length RL,relative width RW,relative area RA and Vascularization index Ⅵ of pterygium.Results After the follow-up,there were 7 lost cases,and finally 182 cases were included in the study.There was no significant difference in sex,comorbidity,smoking,drinking and family history between the two groups(P＞0.05).There were significant differences in pterygium RL,RW,RA,VI and vascular endothelial growth factor(VEGF)between two groups(P＜0.05).Multivariate Logistic regression results showed that VEGF[OR=0.695,95％CI(0.568,0.851)],RL[OR=0.920,95％CI(0.876,0.966)],RA[OR=0.871,95％CI(0.784,0.969)]and VI[OR=0.911,95％CI(0.867,0.957)].Pearson correlation analysis showed that there was a positive correlation among RL,RW,RA and VI(P＜0.05).Conclusion There is a positive correlation between RL,RW,RA and VI of pterygium,and RL,RW,VI and VEGF are related factors affecting the recurrence of pterygium after operation.
关键词
翼状胬肉/复发/病情特征/血管内皮生长因子/相关性Key words
pterygium/recurrence/characteristics of illness/vascular endothelial growth factor/correlation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据