A Comparative Study on the Efficacy of Different Artificial Dermis Combined with Autologous Blade-thick Skin Transplantation in Repairing Wounds with Bone and Tendon Exposure
Objective The aim of this study was to investigate the influence of different artificial dermis combined with autologous blade-thick skin grafts on transplantation effects and aesthetic effects in patients with wounds with bone and tendon exposure.Methods The general clinical data of 60 patients with wounds with bone and tendon exposure who underwent wound repair in the hospital from May 2019 to May 2022 were analyzed retrospectively.Among them,37 patients treated with double layer artificial leather for quick healing combined with autologous blade-thick skin grafts were defined as the control group,and 23 patients treated with domestic double-layer artificial dermis combined with autologous blade-thick skin grafts were defined as the study group.Graft effect and survival of skin grafts were compared between the two groups.Results There was no significant difference in the frequency of skin grafting,the incidence of complications,and the survival rate of skin grafts between the two groups(P＞0.05).The interval time of skin grafting in the study group was longer than that in the control group(P＜0.05).There were no significant differences in the levels of interleukin-1,tumor necrosis factor,interleukin-12,and interferon-γ between the two groups at 3,7,and 14 days after treatment(P＞0.05).There were no significant differences in the levels of transforming growth factor-β1 and vascular endothelial growth factor between the two groups 3 days after treatment(P＞0.05),but the levels of transforming growth factor-β1 and vascular endothelial growth factor in the study group were lower than those in the control group 7 and 14 days after treatment(P＜0.05).At 3 months after treatment,there was no significant difference in Vancouver Scar Scale score between the two groups(P＞0.05).Conclusion Domestic double-layer artificial dermis and double layer artificial leather for quick healing respectively combined with autologous blade-thick skin grafts can achieve equivalent effects in repairing wounds with bone and tendon exposure.However,the interval between grafts of the former is longer,which may be related to the slightly lower level of growth factor in wound tissues.
artificial dermisautogenous blade-thick skintransplantationbone and tendon exposurewound
国家科技期刊平台
NSTL
万方数据
维普
