Study on the Effect of Serum Containing Complex Peptides on Improving Skin Aging
Objective To observe the effect of serum containing complex peptides on aging skin.Methods In vitro experiments,human skin fibroblast(HSF)cell proliferation experiment and determination of type Ⅰ collagen content in HSF.In humans,a randomized,double-blind,self-controlled trial with negative control was performed.Thirty subjects were selected,and the test product which contains complex peptides and control product without complex peptides were used in the morning and evening.Skin elasticity measurements,VISIA photography and skin ultrasound measurements were performed at baseline(D0),day 14(D14)and day 28(D28).Subject subjective evaluation was performed on day 28(D28).Results In vitro experiment showed that the test sample could significantly promote the activity of human skin fibroblast(HSF)and the generation of typeⅠ collagen.The results of human evaluation showed that the skin elasticity of the test side was significantly improved compared with that of D0(P＜0.001)after 28 days of using the test sample and the matching product.Poreometer values of skin on the test side were lower than baseline values in D14 and D28(P＜0.001),but there was no significant difference in the properties and poreometer values at different time points in the control group(P＞0.05).According to the skin ultrasound observation,after 28 days,compared with the baseline(D0),the high-echo area in the dermis of the skin on test side was significantly increased,the dermis density was increased,and the effective case rate was 90％,which was significantly better than the control side.Subject subjective evaluation showed that after 28 days,skin moisture and small wrinkles on both sides were improved compared with baseline value(D0)and without significant difference(P＞0.05),skin firmness and elasticity on the test side were significantly better than those on the control side(P＜0.05).Conclusion The test samples can significantly enhance the HFS activity,promote the generation of type Ⅰ collagen,significantly improve the elasticity of facial skin,significantly reduce facial pores,increase dermal density,and help to improve skin aging.
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维普
