The Biological Changes of Human NK Cell Subsets and Their Relationship with Aging
Natural kill cells(NK cells)is a kind of innate immune lymphoid cells(ILP),which is the third major type of lymphocyte besides T cells and B cells.It is characterized by rapid reaction without antigen sensitization to produce non-specific killing effect.NK cells induce apoptosis of target cells by secreting perforin,granzyme,cytokines and chemokines,and can also express Fc receptor(CD 16),which mediates antibody-dependent cell-mediated cytotoxicity(ADCC).With aging,the function of the immune system decreases,and NK cells initiate adaptive immune response disorders,which cannot mobilize effective immune responses and other physiological phenomena,leading to the occurrence of aging-related diseases such as infection and tumor.In this paper,the biological changes of NK Cells Subsets in the whole life cycle are discussed to explore the relationship between NK cells and aging,so as to lay a foundation for the clinical application of NK cells.
NK cells subsetsagingimmune responseinfectiontumor
国家科技期刊平台
NSTL
万方数据
维普
