Clinical Observation of Platelet-rich Plasma and Concentrated Growth Factor in the Repair of Diabetic Foot Wounds
Objective To investigate the clinical effect of Platelet rich plasma(PRP)and Concentrated growth factor(CGF)in repairing diabetic foot wounds.Methods The clinical data of 90 patients with diabetic foot admitted to author's hospital from June 2017 to October 2022 were retrospectively analyzed.According to the different treatment methods,the patients were divided into CGF group,PRP group and conventional treatment group,with 30 cases in each group.The number of wound dressing changes,healing time,positive rate of bacterial culture,adverse reactions,and total effective rate of treatment were statistically compared among the three groups.Results The frequency of dressing change and wound healing time of the three groups were compared with CGF group＜PRP group＜conventional group(P＜0.05).After 1 and 2 weeks of treatment,the positive rates of bacterial infection in the three groups were as follows:CGF group＜PRP group＜conventional group(P＜0.05).There was statistically significant difference in the total effective rate among the three groups(P＜0.05).The total effective rates in CGF group and PRP group were higher than those in conventional group(P＜0.05).There was no significant difference in the total effective rate between CGF group and PRP group(P＞0.05).There were no obvious adverse reactions in the three groups.Conclusion As platelet active substances,CGF and PRP can promote wound healing and play an anti-inflammatory and antibacterial role.Compared with PRP,CGF can shorten the wound healing time,reduce the number of dressing changes,and have better bacteriostatic effect;but there is no significant difference in the total treatment efficiency between the two groups.
国家科技期刊平台
NSTL
万方数据
