目的:探讨强脉冲光(Intense pulsed light,IPL)联合0.03%他克莫司软膏及皮肤屏障修复精华乳治疗红斑毛细血管扩张型玫瑰痤疮的临床效果.方法:将2021年1月-2022年12月笔者医院收治的63例红斑毛细血管扩张型玫瑰痤疮(Erythema telangiectasia rosacea,ETR)患者按照随机数字表法分为观察组(31例)和对照组(32例).对照组给予0.03%他克莫司软膏涂抹联合皮肤屏障修复精华乳治疗,观察组在对照组基础上行IPL治疗.对比两组治疗效果、症状评分、皮肤屏障功能以及随访期间不良反应情况.结果:治疗后观察组总有效率96.77%,高于对照组75.00%(P＜0.05);治疗后两组患者颜面部瘙痒、灼热、紧绷感等症状均明显缓解,面颊部持续红斑、毛细血管扩张显著消退;且观察组各临床症状评分均低于对照组(P＜0.05);治疗后观察组患者红斑指数和皮肤经皮水分流失量(Trans epidermal water loss,TEWL)均低于对照组,观察组油脂及表皮含水量均高于对照组(P＜0.05);随访期间两组总不良反应率差异无统计学意义(P＞0.05).结论:强脉冲光联合0.03%他克莫司软膏及皮肤屏障修复精华乳治疗ETR疗效确切,能显著改善患者临床症状评分,提高皮肤屏障功能,安全性较高.
Clinical Effects of Intense Pulsed Light Combined with 0.03%Tacrolimus Ointment and Essence Lotion for Repairing Skin Barrier in the Treatment of Erythema Telangiectasia Rosacea
Objective To investigate the clinical effects of intense pulsed light(IPL)combined with 0.03%tacrolimus ointment and essence lotion for repairing skin barrier in the treatment of erythema telangiectasia rosacea(ETR).Methods From January 2021 to December 2022,63 patients with ETR were selected as the research objects,and divided into observation group(31 patients treated with IPL combined with essence lotion for repairing skin barrier)and control group(32 patients treated with 0.03%tacrolimus ointment)according to random digital tables.Treatment effects,symptom scores,skin barrier function indicators such as transepidermal water loss(TEWL),erythema index,skin moisture content and sebum,and the incidence rates of adverse reactions in the two groups during follow-up were compared.Results The total effective rate in the observation group was 96.77%,higher than 75.00%in the control group(P＜0.05).After treatment,facial pruritus,burning,tightness,persistent erythema and telangiectasia on the cheek of both groups were significantly alleviated.After treatment,clinical symptom scores of the two groups decreased,and the observation group had lower scores than the control group(P＜0.05).After treatment,erythema index and TEWL in the two groups decreased,and were lower in the observation group than in the control group.Sebum and skin moisture content increased,and were higher in the observation group than in the control group(P＜0.05).The total incidence of adverse reactions in the observation group during follow-up was 6.45%,lower than 25.00%in the control group(P=0.082).Conclusion Intense pulsed light combined with 0.03%tacrolimus ointment and essence lotion for repairing skin barrier is effective in the treatment of ETR.It can significantly relieve clinical symptoms,improve skin barrier function and reduce adverse reactions with high safety.
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