Efficacy and Safety of 1 064 nm Nd∶YAG Laser Treatment in Infantile Hemangioma:A Meta-analysis
Objective The meta-analysis system was used to evaluate the efficacy and safety of Nd:YAG 1 064 nm laser in the treatment of infantile hemangioma.Methods Cochrane Library,PubMed,Med of science,CNKI,VIP and Wanfang database were searched.All relevant randomized controlled trials of Nd:YAG 1 064 nm laser treatment of infant hemangioma,up to September 10,2022,were retrieved.Quality evaluation of all the studies were included.The meta analysis was performed using RevMan5.4.1 software.Results A total of 8 randomized controlled studies were enrolled,with a total of 835 cases of infantile hemangioma.The results showed that there was no statistically significant difference in the efficacy between the 1 064 nm Nd∶YAG laser therapy and propranolol alone in the treatment of hemangioma(P＞0.05).The 1 064 nm Nd∶YAG laser therapy was less safer than propranolol alone in the treatment of hemangioma.The efficacy and safety of 1 064 nm Nd∶YAG laser alone in the treatment of hemangiomas were lower than that of combined oral propranolol treatment;the efficacy of 1 064 nm Nd∶YAG laser in the treatment of hemangiomas was higher than that of topical timolol alone,but the safety was lower than that of topical timolol alone;the efficacy and safety of 1 064 nm Nd∶YAG laser alone in the treatment of hemangiomas was The efficacy and safety of 1 064 nm Nd∶YAG laser alone in the treatment of hemangiomas are lower than that of laser combined with timolol(all P＜0.05).There was no statistically significant difference in the efficiency between 1 064 nm Nd∶YAG laser therapy and 1 064 nm Nd∶YAG laser therapy combined with polycinnamon(P＞0.05).Conclusion This meta-analysis provides strong evidences that Nd:YAG 1 064 nm laser therapy of hemangioma was more effective and less safer than traditional drugs.Nd:YAG 1 064 nm laser in combination with drugs can improve the efficiency and safety to some extent in the treatment of hemangioma.
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