Ultra-pulsed Fractional CO2 Laser Combined with Silicone Gel for the Treatment of Hypertrophic Scar after Deep Ⅱ Degree Burns on Face and Neck
Objective To observe the clinical effects of utrapulse fractional CO2 laser combined with silicone gel on hyperplastic scarring(HS)after Deep Ⅱ degree burns on the face and neck.Methods One hundred and eighteen patients with HS after DeepⅡ degree burns on the face and neck admitted to author's hospital from May 2020 to February 2023 were selected and divided into a control group(treated with silicone gel,59 patients)and a combined group(treated with utrapulse fractional CO2 laser combined with silicone gel,59 patients)using the random number table method.The clinical efficacy,visual analogue pain scale(VAS)score,Vancouver scar scale(VSS)score,scar thickness,scar echodensity,growth factor indexes[transforming growth factor-β1(TGF-β1),epidermal growth factor(EGF)]and the occurrence of adverse reactions were compared between the two groups.Results After 3 months of treatment,the total effective rate of the combined group was 98.31%,which was higher than 84.75%of the control group(P＜0.05).The VAS score and VSS score after treatment in the combined group were lower than those in the control group(P＜0.05).The scar thickness after treatment was lower in the combined group than in the control group(P＜0.05),while the scar echogenic density was higher than in the control group(P＜0.05).TGF-β1 and EGF were lower in the combined group than in the control group after treatment(P＜0.05).During the treatment,the incidence of adverse reactions in the combined group and the control group was 11.86%and 8.47%,respectively,but the difference was not statistically significant(P＞0.05).Conclusion Utrapulse fractional CO2 laser combined with silicone gel can improve clinical efficacy,relieve pain symptoms,improve scar condition,promote scar regression,and regulate growth factor levels in patients with HS after Deep Ⅱ degree burns on the face and neck,and it is safe and reliable.
face and neckdeep Ⅱ degree burnshyperplastic scarutrapulse fractional CO2 lasersilicone gelclinical efficacy
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