Changes of HMGB1,sICAM-1,IL-33 and TSLP in Orthodontic Gingival Sulcus Fluid and Correlation with Periodontal Indicators in Periodontitis
Objective To investigate the dynamic changes of gingival crevicular fluid high mobility group box-1 protein(HMGB1),soluble intercellular adhesion molecule-1(sICAM-1),interleukin-33(IL-33),thymic stromal lymphopoietin(TSLP)levels before and after orthodontic treatment of periodontitis and their correlation with periodontal indexes.Methods A total of 124 patients undergoing orthodontic treatment with periodontitis in author's hospital from January 2019 to August 2021 were selected as the research objects.According to the treatment effect,they were divided into good curative effect(n=104)and poor curative effect(n=20).The clinical data,periodontal index and gingival crevicular fluid index levels of patients with different curative effects were compared,and the factors affecting the curative effect of orthodontic treatment of periodontitis and the correlation between gingival crevicular fluid index and periodontal index were analyzed.A receiver operating characteristic curve(ROC)was drawn to evaluate the evaluation value of gingival crevicular fluid indexes for the prognosis of patients.Results The periodontal indexes PLI,PD and BI of patients with good curative effect were lower than those with poor curative effect after treatment,and the difference was statistically significant(P＜0.05).The levels of gingival crevicular fluid HMGB1,sICAM-1,IL-33 and TSLP in patients with good curative effect were lower than those with poor curative effect,and the difference was statistically significant(P＜0.05).Logistic regression analysis showed that the periodontal indexes PLI,PD,BI and the levels of gingival crevicular fluid HMGB1,sICAM-1,IL-33 and TSLP after treatment were all influential factors for the poor efficacy of orthodontic treatment of periodontitis(P＜0.05).The levels of gingival crevicular fluid HMGB1,sICAM-1,IL-33,TSLP in patients with periodontitis orthodontic treatment were positively correlated with periodontal indexes PLI,PD,BI(P＜0.05).The combined level of HMGB1,SICAM-1,IL-33 and TSLP in postoperative gingival crevicular fluid had the highest AUC of 0.934 in evaluating the efficacy of orthodontic treatment in patients with periodontitis,indicating a high evaluation efficiency.Conclusion The changes of gingival crevicular fluid HMGB1,sICAM-1,IL-33 and TSLP levels before and after orthodontic treatment of periodontitis are closely related to the periodontal status of patients.The combined detection can provide reference for clinical evaluation of the treatment effect and actively improve the treatment plan.
periodontitisorthodontic treatmentgingival crevicular fluidhigh mobility group box-1 proteininterleukin-33plaque indexprobing depth
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