Therapeutic Effect of Peripheral Blood Stem Cells Combined with Exosomes on Diabetic Foot Ulcer Wounds
Objective To investigate the therapeutic effect of autologous PBSCs combined with SC-Exos on diabetic foot ulcer(DFU)wound.Methods Sixty patients with ulcerated feet were randomly divided into control group,SC-Exos external application group(treatment group A),PBSCs injection group(treatment group B),and PBSCs combined with SC-Exos group(treatment group C)with 15 feet in each group.On the basis of conventional treatment(control group),SC-Exos external application or/and PBSCs peripheral injection were given respectively,and the second dose was given 2 weeks later.The ulcer wound area,granulation morphology score,foot pain,cold sensation and lameness score,peak systolic velocity(PSV),vessel diameter and total effective rate of the patients were observed at 4,8 and 12 weeks after the first dose.Results After treatment,the wound area changes,granulation shape scores,pain,cold feeling and lameness scores of the affected foot,PSV and vessel diameter of the dorsal foot artery in the four groups were significantly improved compared with before treatment.Pairwise comparison of all indicators among groups showed no statistical significance between treatment group A and treatment group B(P＞0.05).There were statistically significant differences among the other groups(P＜0.05),and the results of C indexes in the treatment group were significantly better than those in the other groups(P＜0.05).After 12 weeks of treatment,the control group,treatment group A and treatment group B were compared pair-to-pair,and the difference was not statistically significant(P＞0.05).The total effective rate of treatment group C was significantly higher than that of other groups(P＜0.05).Conclusion PBSCs,SC-Exos and their combined intervention can promote wound healing in patients with severe diabetic foot ulcer(DFU),improve symptoms and blood flow of the affected foot,and the combined application of PBSCs and SC-Exos is better than the single application.
万方数据
维普
