Clinical Observation of Fractional CO2 Laser Combined with PRP in the Treatment of Scars after Suture of Facial Trauma
Objective To explore the effect of using fractional CO2 laser combined with platelet-rich plasma(PRP)in the treatment of scar after sutured facial trauma.Methods A total of 152 patients who underwent scar prevention treatment after plastic surgery and suture for facial trauma from March 2020 to March 2022 were selected.They were randomly divided into the laser group(50 cases),the PRP group(51 cases)and the combination group(51 cases).The laser group was treated with fractional CO2 laser.The PRP group was treated with PRP microneedle injection.The combination group was treated with fractional CO2 laser combined with PRP.Therapeutic effects,inflammatory factor levels,the difference in thickness between wound skin and normal skin,and Vancouver scar scale(VSS)scores were compared among the three groups.Results After 6 months of treatment,the total effective rate in the combination group was higher than those in the PRP group and the laser group(P＜0.05).Compared with before treatment,the thickness of scars and normal skin in the three groups after 3 months,6 months and 1 year of treatment decreased gradually,the difference in thickness between wound skin and normal skin in the combination group was smaller than that in the PRP group and the laser group(P＜0.05).Meanwhile,the difference in thickness between wound skin and normal skin in the PRP group was smaller than that in the laser group(P＜0.05).Compared with before treatment,VSS scores of the three groups after 3 months,6 months and 1 year of treatment decreased gradually.VSS scores of the combination group were lower than those of the PRP group and the laser group(P＜0.05),and VSS scores of the PRP group were lower than those of the laser group(P＜0.05).After 6 months of treatment,the levels of tumor necrosis factor alpha(TNF-α),interleukin-2(IL-2)and interleukin-6(IL-6)in all groups decreased.The levels of inflammatory factors in the combination group were lower than those in the PRP group and the laser group(P＜0.05),and the levels of inflammatory factors in the PRP group were lower than those in the laser group(P＜0.05).Conclusion Fractional CO2 laser combined with PRP is effective in preventing and treating scars in patients with facial trauma after suturing.The combined treatment can lower inflammatory factor levels,and significantly improve the color,thickness and texture of scars.
facial traumascarfractional CO2 laserplatelet-rich plasmainflammatory factor
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