Observation on the Therapeutic Effect of Sibai Qucuo Decoction Combined with Minocycline Hydrochloride in the Treatment of Damp-heat Accumulated Acne and Levels of TLR2 and IL-4 in Peripheral Blood
Objective To observe the efficacy of Sibai Qucuo Decoction combined with Minocycline hydrochloride in the treatment of acne and the levels of Toll like receptor 2(TLR2)and Interleukin 4(IL-4)in peripheral blood Monocyte.Methods A total of 120 acne patients admitted to the author's hospital from January 2020 to December 2022 were selected for this study.The patients were divided into the observation group(Sibai Qucuo Decoction combined with minocycline hydrochloride,60 cases)and the control group(minocycline hydrochloride treatment,60 cases)according to the random number table method.The treatment effects of the two groups were compared.The skin scores for acne,inflammatory papules,pustules,nodules,and cysts of the two groups were compared before and after treatment.The levels of TLR2 and IL-4 in peripheral blood were compared,as well as the scores of emotional function,self-perception,social function,and acne symptoms.Additionally,the adverse reactions of the two groups were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the skin scores of both groups decreased significantly,with the observation group showing significantly lower scores than the control group(P<0.05).The levels of TLR2 and IL-4 in peripheral blood of both groups significantly decreased after treatment,with the observation group showing significantly lower levels than the control group(P<0.05).The emotional function,self-perception,social function,and acne symptom scores of the two groups significantly increased after treatment,with the observation group showing higher scores than the control group(P<0.05).The total incidence of adverse reactions in the observation group and the control group were 10% and 11.67%,respectively,with no significant difference(P>0.05).Conclusion Sibai Qucuo Decoction combined with minocycline hydrochloride can effectively relieve the clinical symptoms of acne patients,reduce the levels of TLR2 and IL-4 in peripheral blood,and improve the quality of life of patients with acne without causing serious adverse reactions,indicating high safety.