Efficacy of Recombinant Mussel Mucin Combined with Tacrolimus Ointment and Antihistamine in the Treatment of Hormone-dependent Dermatitis of the Face and Its Effect on Skin Barrier Indicators
Objective Study on the efficacy of recombinant mussel mucin combined with tacrolimus and antihistamines in the treatment of facial hormone dependent dermatitis(referred to as facial dermatitis)and its impact on skin barrier indicators.Methods One hundred and thirty-one patients with facial dermatitis referred to dermatology outpatient clinic in the author's hospital from April 2020 to December 2022 were enrolled,and assigned into two groups according the random number table methods.All patients received routine interventions,based on this,control group(n=65)was given tacrolimus plus antihistamine therapy,while study group(n=66)received recombinant mussel adhesive protein combined with tacrolimus and antihistamine.Treatment in both groups lasted for 4 weeks.Then the outcome criteria including skin barrier function(casual sebum content,stratum corneum hydration,transepidermal water loss),scores of objective clinical signs and subjective symptoms,clinical efficacy,and adverse reactions were compared between two groups.Results After treatment,an increase in casual sebum content and stratum corneum hydration along with a decrease in transepidermal water loss were observed in both groups,and study group had higher casual sebum content and stratum corneum hydration,and lower transepidermal water loss than those in control group(P＜0.05).After discontinuation of the drug,the scores of objective clinical signs and subjective symptoms decreased in both groups,and study group scored lower than control group(P＜0.05).The overall efficacy rate was 93.94% in study group,which was higher than 81.54% in control group(P＜0.05).The adverse reaction rate yielded no statistical difference between two groups(P＞0.05).Conclusion Application of recombinant mussel adhesive protein combined with tacrolimus ointment and antihistamine in the treatment of facial dermatitis can effectively improve the clinical symptoms,promote the restoration of skin barrier function and cause no serious adverse effects.
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