Efficacy of 308 nm Excimer Laser Combined with Compound Betamethasone in the Treatment of Patients with Advanced Vitiligo and Its Influence on Recurrence
Objective To explore the clinical effect of 308 nm excimer laser combined with compound betamethasone in the treatment of patients with vitiligo and its influence on disease recurrence.Methods 105 patients with vitiligo who were treated in dermatology clinic of Suzhou Hospital of Anhui Medical University(Suzhou Municipal Hospital)from June 2019 to December 2022 were selected and divided into two groups according to random coin tossing method,including 53 cases in observation group and 52 cases in control group.Both groups were treated with 308 nm excimer laser,and the observation group was treated with compound betamethasone on this basis.The skin area,antibodies and pigment degree were observed after 3 months of treatment.End of treatment follow-up observation for 12 months,the recurrence of vitiligo was detected.Results After study and treatment,the skin area in observation group was significantly smaller than that in control group(P<0.05).After treatment,the levels of thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)and thyroid receptor antibody(TYR IgG)were significantly lower in observation group than those in control group(P<0.05).The proportion of pigment recovery degree above grade 3 in observation group after treatment was significantly higher than that in control group(P<0.05).After 3,6 and 12 months of treatment,the vitiligo disease activity index(VIDA)score in observation group was significantly lower compared with that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of vitiligo in observation group within 12 months after treatment was significantly lower than that in control group(P<0.05).Conclusion 308 nm excimer laser combined with compound betamethasone is more effective than single use in the treatment of patients with vitiligo,and the former one can more significantly improve the skin lesions,increase the level of autoimmunity,enhance the overall pigment recovery degree,and reduce the long-term recurrence rate of patients,and it has clinical application value.
308 nm excimer lasercompound betamethasonevitiligoskin lesion arearecurrence status