Effect of CGF on Endothelial Cell Proliferation in Dental Pulp Vascular Regeneration
Objective To study the effect of concentrated growth factor(CGF)on endothelial cell proliferation in dental pulp vascular regeneration.Methods 84 children with pulp necrosis of young permanent teeth who planned to undergo pulp vascular regeneration in the author's hospital from March 2019 to March 2021 were selected as the research objects.They were randomly divided into CGF group and control group,with 42 cases in each group.Both groups were treated with pulp vascular regeneration.The CGF group was covered with CGF and the control group was covered with inorganic trioxide polymer(MTA).The clinical effects of the two groups were observed 6 months after operation,The changes of root size[root length,apical hole diameter,imaging root area(RRA)]were observed before and 6 months after operation,The recovery of dental pulp vitality in the two groups was observed 6 months after operation,The expression of vascular endothelial cell surface markers[platelet endothelial cell adhesion molecule(CD31),vascular endothelial growth factor receptor 2(VEGFR2),vascular endothelial cadherin]before and after operation were measured,the complications of the two groups during follow-up were counted.Results The total effective rate was 100.00% in the observation group and 97.62% in the control group,with no significant difference(P＞0.05).6 months after operation,the root length and pra of CGF group were significantly higher than those before operation and 6 months after operation in the control group,and the diameter of apical foramen was significantly lower than that before operation and 6 months after operation in the control group(P＜0.05).The positive rate of dental pulp viability test in CGF group was 40.48% (17/42)and that in control group was 19.05% (8/40).The difference was statistically significant(P＜0.05).The expression levels of CD31,VEGFR2 and ve cadherin in CGF group were higher than those before operation and 6 months after operation in control group(P＜0.05).There was no significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion CGF used in dental pulp vascular regeneration can effectively promote the continuous development of young permanent teeth,restore the vitality of some dental pulp,and improve the proliferation of endothelial cells of affected teeth,which is worthy of clinical promotion.
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