再生医学对糖尿病足创面修复作用的研究进展
Research Progress of Regenerative Medicine in Repairing Diabetic Foot Ulcers
彭艳 1戴雯婷 1聂君毅 1谢汶芹 1曹硕 1侯秀英 2李勤雨 2袁佩雯1
作者信息
- 1. 山西医科大学第一临床医学院 山西 太原 030001
- 2. 山西医科大学第一医院整形外科 山西 太原 030001
- 折叠
摘要
糖尿病足溃疡(Diabetic foot ulcers,DFUs)是糖尿病晚期的严重并发症,是糖尿病患者致残、致死的主要原因之一,在我国发病率逐年升高,已成为加重社会负担的重大公共卫生问题.DFUs由内外多重因素导致,包括糖代谢紊乱所致皮肤微环境变化、感染、创伤等,往往难以治愈,消耗高昂的医疗资源.因此,找到更有效的疗法非常重要.目前,糖尿病足创面的常规治疗已渐渐被再生医学疗法如干细胞、富血小板血浆、外泌体和功能性RNAs等取代.本文根据最新研究进展对糖尿病足难愈创面的再生医学修复方式予以综述.
Abstract
Diabetic foot ulcers(DFUs)are serious complications of advanced diabetes and one of the main causes of disability and death in diabetic patients.The incidence of DFUs is increasing year by year in China and has become a major public health problem that increases social burden.DFUs is caused by multiple internal and external factors,including changes in skin microenvironment,infection and trauma caused by glucose metabolism disorders,which are often difficult to cure and consume high medical resources.So finding more effective treatments is very important.At present,the conventional treatment of diabetic foot wounds has been gradually replaced by regenerative medicine therapy such as stem cells,platelet-rich plasma,exosomes and functional RNAs.Based on the latest research progress,this paper reviews the regenerative medical repair methods of refractory diabetic foot wounds.
关键词
糖尿病足溃疡/干细胞/富血小板血浆/外泌体/核糖核酸Key words
diabetic foot ulcers/stem cells/platelet-rich plasma/exosomers/ribonucleic acid引用本文复制引用
基金项目
山西省重点研发计划项目(201903D3211125507310952296135581)
出版年
2024
国家科技期刊平台
NSTL
万方数据