Aesthetic Effect of Fractional CO2 Laser Combined with Triamcinolone Acetonide Acetate in the Treatment of Early-stage Facial Hypertrophic Scars in Pediatric Patients
Objective To explore the aesthetic effect of fractional CO2 laser combined with transdermal delivery of triamcinolone acetonide aqueous(TAA)in the treatment of early-stage facial hypertrophic scars in pediatric patients.Methods One hundred and fifty-eight pediatric patients with early-stage facial hypertrophic scars in the author's hospital from January 2020 to December 2022 were enrolled,and therapy using a water light injection device(control group 1,n=51),fractional CO2 laser(control group 2,n=54)or fractional CO2 laser plus transdermal delivery of TAA(study group,n=53).Then the clinical efficacy,aesthetic effect[patient and observer scar assessment scale(POSAS)],serum scar growth factors[transforming growth factor-β1(TGF-β1),bone morphogenetic protein-7(BMP-7),vascular endothelial growth factor(VEGF)],adverse reactions,total medical costs and parental satisfaction were compared among three groups.Results The total efficacy rate was 98.11％in study group,which was higher than 84.31％in control group 1 and 87.04％in control group 2,with statistical difference(P＜0.05).An improvement was detected in overall scores of observer scar assessment scale(OSAS)and patient scar assessment scale(PSAS)scores in both groups after treatment(P＜0.05).Furthermore,study group had lower pigmentation score and overall score in OSAS as well as lower pain score and overall score in PSAS than those in control group 1 and control group 2(all P＜0.05).A reduction in serum levels of TGF-β1,BMP-7 and VEGF was observed in all three groups after treatment,and the reduction was most notable in study group than in control group 1 and control group 2(P＜0.05).The medical cost in study group was lower than that in control group 1 and that in control group 2(P＜0.05).The adverse reaction group yielded no statistical difference between two groups(P＞0.05).The patient satisfaction rate was 100.00％in study group,which was higher than 88.24％in control group 1 and 90.74％in control group 2(P＜0.05).Conclusion Application of fractional CO2 laser combined with triamcinolone acetonide acetate in the treatment of early-stage facial hypertrophic scars in pediatric patients can effectively reduce the levels of growth factors in scar formation,attenuate pigmentation,and improve the aesthetic effect and patient satisfaction rate.
fractional CO2 lasertriamcinolone acetonide acetatehypertrophic scaraesthetic effect
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