Cosmetic Effect of 420 nm Intense Pulsed Light Combined with Long-pulsed 1 064 nm Nd∶YAG Laser in the Treatment of Rosacea
Objective To observe the cosmetic efficacy of 420 nm intense pulsed light combined with long-pulsed 1,064 nm Nd∶YAG laser in the treatment of rosacea.Methods A total of 150 patients with rosacea admitted to the hospital between June 2020 and July 2023 were enrolled and randomly divided into three groups:group A(420 nm intense pulsed light),group B(long-pulsed 1,064 nm Nd∶YAG laser),and group C(420 nm intense pulsed light combined with long-pulsed 1,064 nm Nd∶YAG laser),with 50 patients in each group.Clinical efficacy,scores of skin lesion symptoms,skin barrier function,adverse reactions,and dermatology life quality index(DLQI)scores were compared among the three groups..Results The clinical response rate in group C was higher than that in group A and group B(96.00％vs.80.00％vs.82.67％,P＜0.05).After treatment,the scores for skin lesion symptoms decreased in all three groups,with group C showing lower scores compared to group A and group B(P＜0.05).The number of erythematous lesions and transepidermal water loss(TEWL)decreased in all groups,with group C showing more significant reductions than groups A and B,while the water content of the stratum corneum increased,being higher in group C than in group A and group B(P＜0.05).The incidence of adverse reactions did not differ significantly among the three groups(8.00％vs.6.00％vs.10.00％,P＞0.0).After 8 weeks of treatment,DLQI scores decreased in all three groups,with group C showing lower scores than group A and group B(P＜0.05).Conclusion The combination of 420 nm intense pulsed light and long-pulsed 1,064 nm Nd∶YAG laser demonstrates significant clinical efficacy in rosacea patients.This combination therapy effectively improves skin lesion symptoms,enhances skin barrier function,and improves the quality of life,with a favorable safety profile.
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