Objective To investigate the efficacy and aesthetic impact of fractional CO2 laser combined with 30％glacial acetic acid in the treatment of onychomycosis.Methods A total of 58 patients with onychomycosis who attended the dermatology clinic of the author's hospital from February 2022 to February 2023 were selected.The control group received topical treatment with 30％glacial acetic acid,while the study group was treated with a combination of fractional CO2 laser and 30％glacial acetic acid,followed by a 3-month follow-up.The efficacy of the treatments was assessed after 3 months,and treatment satisfaction between the two groups was compared.Measurements of the length of diseased and healthy nail plates were conducted at 1 and 3 months post-treatment.The incidence of adverse reactions was also compared between the groups.Results The overall effective rate in the study group was 68.97％,significantly higher than the 41.38％observed in the control group(P＜0.05).The overall treatment satisfaction in the study group was 65.52％,markedly higher than the 37.93％in the control group(P＜0.05).At both the 3-month and 6-month marks,the length of the diseased nail plate in the study group was significantly shorter than in the control group(P＜0.05),while the length of the healthy nail plate was significantly longer(P＜0.05).No adverse reactions,such as subungual hemorrhage or nail defects,were reported in either group during the treatment period.Liver and renal function remained normal,and routine urine and blood tests showed no abnormalities.Conclusion The combination of fractional CO2 laser with 30％glacial acetic acid is effective in treating onychomycosis,protecting the skin barrier function,and improving aesthetic outcomes.
关键词
点阵CO2激光/30％冰醋酸/甲真菌病/疗效/皮肤屏障功能/美观度
Key words
fractional CO2 laser/30％glacial acetic acid/onychomycosis/efficacy/skin barrier function/aesthetics
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