Effect Analysis of rbFGF Combined with HCQ and RHCD in the Treatment of Rosacea
Objective To investigate the effect of recombinant bovine basic fibroblast growth factor(rbFGF)combined with hydroxychloroquine sulfate(HCQ)and recombinant human collagen dressing(RHCD)on facial appearance and skin lesions in patients with rosacea.Methods From February 2019 to January 2023,83 patients with rosacea admitted to Beijing Anzhen Hospital affiliated with Capital Medical University were selected.The cohort included 31 cases of erythematotelangiectatic rosacea,27 cases of papulopustular rosacea,and 25 cases of phymatous rosacea.All patients were treated with a combination of HCQ,RHCD,and rbFGF for 8 weeks.Clinical efficacy,treatment satisfaction,skin lesion severity before and after 8 weeks of treatment,and levels of peripheral blood nesfatin-1,Toll-like receptor 2(TLR2),serum myeloperoxidase(MPO),and soluble interleukin-2 receptor(sIL-2R)were analyzed.Quality of life(QoL)scores and facial appearance scores were also assessed across different types of patients.Results After 8 weeks of treatment,the total effective rate in patients with erythematotelangiectatic and papulopustular rosacea was significantly higher(P＜0.05).Compared to baseline,after 8 weeks of treatment,scores for rash color,quantity,and burning/itching sensation,as well as levels of peripheral blood nesfatin-1,TLR2,serum MPO,and sIL-2R,decreased across all patient types.The decreases were more pronounced in patients with erythematotelangiectatic and papulopustular rosacea compared to those with phymatous rosacea.QoL scores,self-perception,emotional function,acne symptoms,social function,and visual analogue scale(VAS)scores all improved,with greater increases observed in the erythematotelangiectatic and papulopustular groups compared to the phymatous group(P＜0.05).Conclusion Treatment with rbFGF combined with HCQ and RHCD in patients with rosacea helps to alleviate skin lesions,reduce inflammatory response,improve quality of life and treatment satisfaction,and enhance facial appearance.The therapeutic effect is more pronounced in patients with erythematotelangiectatic and papulopustular rosacea compared to those with phymatous rosacea.
rosaceahydroxychloroquine sulfaterecombinant bovine basic fibroblast growth factorrecombinant human collagenaesthetic effectlesion
万方数据
维普
