In order to improve the economic value added of comprehensive utilization device of coal-based mixed C4 and reduce the consumption of ligand catalyst for carbonyl synthesis reaction of producing 2-propylheptanol(referred to as 2-PH)product by coal-based mixed C4.Based on the actual case of coal chemical production plant,the optimal operating conditions and process parameters suitable for high and low load operation of industrial plant were found out by optimizing the reaction temperature,hydrogen-carbon ratio,ligand catalyst concentration,reactor water supply operation,buffer solution allocation ratio and injection amount,so as to reduce the decomposition consumption of ligand catalyst,extend the service life of rhodium catalyst,and further increase significantly the economic benefit of coal chemical plant.