首页|Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

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Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at multiple levels during the development,activation and effector phases of T and B cells.These mechanisms are cell-intrinsically programmed and critical in preventing autoimmune diseases.We have witnessed the existence of another type of immune tolerance mechanism that is shaped by lifestyle choices,such as diet,microbiome and microbial metabolites.Short-chain fatty acids(SCFAs)are the most abundant microbial metabolites in the colonic lumen and are mainly produced by the microbial fermentation of prebiotics,such as dietary fiber.This review focuses on the preventive and immunomodulatory effects of SCFAs on autoimmunity.The tissue-and disease-specific effects of dietary fiber,SCFAs and SCFA-producing microbes on major types of autoimmune diseases,including type I diabetes,multiple sclerosis,rheumatoid arthritis and lupus,are discussed.Additionally,their key regulatory mechanisms for lymphocyte development,tissue barrier function,host metabolism,immunity,autoantibody production,and inflammatory effector and regulatory lymphocytes are discussed.The shared and differential effects of SCFAs on different types and stages of autoimmune diseases are discussed.

Short-chain fatty acidsImmune toleranceDiabetes mellitusRheumatoid arthritisLupusMultiple sclerosis

Chang H.Kim

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Department of Pathology,University of Michigan School of Medicine,Ann Arbor,MI 48109,USA

Mary H.Weiser Food Allergy Center,Center for Gastrointestinal Research,and Rogel Center for Cancer Research,University of Michigan School of Medicine,Ann Arbor,MI 48109,USA

This study was supported,in part,by the NIHThis study was supported,in part,by the NIHThis study was supported,in part,by the NIHThis study was supported,in part,by the NIH

R01AI121302R21AI14889801R01AI074745R01AI080769

2023

10.1038/s41423-023-00987-1

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.731
ISSN：1672-7681
年,卷(期)：2023.20(4)
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