首页|PLZF restricts intestinal ILC3 function in gut defense
PLZF restricts intestinal ILC3 function in gut defense
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Group 3 innate lymphoid cells(ILC3s)play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation.The transcription factor PLZF(promyelocytic leukemia zinc finger),encoded by zinc finger BTB domain containing 16(Zbtb16),is highly and transiently expressed in ILC precursors(ILCPs).However,the role of PLZF in regulating ILC3 development and function remains unknown.Here,we show that PLZF was specifically expressed in mature intestinal ILC3s compared with other ILC subsets.PLZF was dispensable for ILC3 development.However,PLZF deficiency in ILC3s resulted in increased innate interleukin-22(IL-22)secretion and protection against gut infection and inflammation.Mechanistically,PLZF negatively regulated IL-22 expression by ILC3s in a cell-intrinsic manner by binding to the IL-22 promoter region for transcriptional repression.Together,our data suggest that PLZF restricts intestinal ILC3 function to regulate gut immune homeostasis.
Shanghai Institute of Immunology,Department of Immunology and Microbiology,and Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
Shanghai Key Laboratory of Tumor Microenvironment and Inflammation,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
Department of Neurosurgery,Center for Immune-Related Diseases at Shanghai Institute of Immunology,Ruijin Hospital,Shanghai Jiao Tong U
Ministry of Science and Technology of ChinagrantNational Natural Science Foundation of ChinaScience and Technology Commission of Shanghai MunicipalityScience and Technology Commission of Shanghai MunicipalityShanghai Municipal Health CommissionShanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases
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