首页|Dendritic cell subsets in cancer immunity and tumor antigen sensing

Dendritic cell subsets in cancer immunity and tumor antigen sensing

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Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses.Due to their ability to cross-present tumor cell-associated antigens to naïve T cells,DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell dissemination.Within an immunosuppressive tumor microenvironment,DC antitumor functions can,however,be severely impaired.In this review,we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions,taking advantage of recent studies showing the phenotype acquisition,transcriptional state and functional programs revealed by scRNA-seq analysis.The therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed.

Dendritic cell subsetsTumor microenvironmentMigrationInnate immune sensingImmune cell deathTumor-derived extracellular vesicles

Annalisa Del Prete、Valentina Salvi、Alessandra Soriani、Mattia Laffranchi、Francesca Sozio、Daniela Bosisio、Silvano Sozzani

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Department of Molecular and Translational Medicine,University of Brescia,Brescia,Italy

Humanitas Clinical and Research Center-IRCCS Rozzano,Milano,Italy

Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti,Department of Molecular Medicine,Sapienza University of Rome,Rome,Italy

IRCCS Neuromed,Pozzilli,IS,Italy

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Italian Association for Cancer ResearchItalian Association for Cancer ResearchMinistero dell'Istruzione,dell'Università e della RicercaMinistero dell'Istruzione,dell'Università e della RicercaMinistero dell'Istruzione,dell'Università e della Ricercaa fellowship from AIRC

AIRC IG-2017/20776 to SSIG-2021/25680MIURPRIN Prot.2017/7J4E752017/8ALPCM_005code 25307

2023

10.1038/s41423-023-00990-6

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.731
ISSN：1672-7681
年,卷(期)：2023.20(5)
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