首页|The translational revolution in atopic dermatitis:the paradigm shift from pathogenesis to treatment

The translational revolution in atopic dermatitis:the paradigm shift from pathogenesis to treatment

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Atopic dermatitis(AD)is the most common inflammatory skin disease,and it is considered a complex and heterogeneous condition.Different phenotypes of AD,defined according to the patient age at onset,race,and ethnic background;disease duration;and other disease characteristics,have been recently described,underlying the need for a personalized treatment approach.Recent advancements in understanding AD pathogenesis resulted in a real translational revolution and led to the exponential expansion of the therapeutic pipeline.The study of biomarkers in clinical studies of emerging treatments is helping clarify the role of each cytokine and immune pathway in AD and will allow addressing the unique immune fingerprints of each AD subset.Personalized medicine will be the ultimate goal of this targeted translational research.In this review,we discuss the changes in the concepts of both the pathogenesis of and treatment approach to AD,highlight the scientific rationale behind each targeted treatment and report the most recent clinical efficacy data.

Atopic dermatitistranslational revolutionbiomarkerseczema

Paola Facheris、Jane Jeffery、Ester Del Duca、Emma Guttman-Yassky

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Laboratory of Inflammatory Skin Diseases,Department of Dermatology,Icahn School of Medicine at Mount Sinai,New York,NY,USA

Humanitas Clinical and Research Center,Department of Dermatology,Rozzano,Milano,Italy

Duke University School of Medicine,Durham,NC,USA

Department of Dermatology,Icahn School of Medicine at Mount Sinai,New York,NY,USA

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2023

10.1038/s41423-023-00992-4

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.731
ISSN：1672-7681
年,卷(期)：2023.20(5)
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