Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications

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外文摘要：Mesenchymal stem/stromal cells(MSCs)are widely distributed in the body and play essential roles in tissue regeneration and homeostasis.MSCs can be isolated from discarded tissues,expanded in vitro and used as therapeutics for autoimmune diseases and other chronic disorders.MSCs promote tissue regeneration and homeostasis by primarily acting on immune cells.At least six different types of MSCs have been isolated from postnatal dental tissues and have remarkable immunomodulatory properties.Dental stem cells(DSCs)have been demonstrated to have therapeutic effects on several systemic inflammatory diseases.Conversely,MSCs derived from nondental tissues such as the umbilical cord exhibit great benefits in the management of periodontitis in preclinical studies.Here,we discuss the main therapeutic uses of MSCs/DSCs,their mechanisms,extrinsic inflammatory cues and the intrinsic metabolic circuitries that govern the immunomodulatory functions of MSCs/DSCs.Increased understanding of the mechanisms underpinning the immunomodulatory functions of MSCs/DSCs is expected to aid in the development of more potent and precise MSC/DSC-based therapeutics.

外文关键词：

Mesenchymal stem cellsDental stem cellsImmunoregulationInflammation

作者：

Peishan Li、Qianmin Ou、Songtao Shi、Changshun Shao

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作者单位：

The First Affiliated Hospital of Soochow University,State Key Laboratory of Radiation Medicine and Protection,Institutes for Translational Medicine,Soochow University,Suzhou,PR China

South China Center of Craniofacial Stem Cell Research,Hospital of Stomatology,Guangdong Provincial Key Laboratory of Stomatology,Sun Yat-Sen University,Guangzhou,PR China

基金：

National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaJiangsu Province International Joint Laboratory for Regenerative Medicine FundNational Center for International Research-Cambridge-Su Genomic Research Center

项目编号：

2021YFA11006002022YFA080730081972682321507105232017B01012

出版年：

2023

DOI：

10.1038/s41423-023-00998-y

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(6)

参考文献量141