首页|Mesenchymal stromal cells in hepatic fibrosis/cirrhosis:from pathogenesis to treatment

Mesenchymal stromal cells in hepatic fibrosis/cirrhosis:from pathogenesis to treatment

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Hepatic fibrosis/cirrhosis is a significant health burden worldwide,resulting in liver failure or hepatocellular carcinoma(HCC)and accounting for many deaths each year.The pathogenesis of hepatic fibrosis/cirrhosis is very complex,which makes treatment challenging.Endogenous mesenchymal stromal cells(MSCs)have been shown to play pivotal roles in the pathogenesis of hepatic fibrosis.Paradoxically,exogenous MSCs have also been used in clinical trials for liver cirrhosis,and their effectiveness has been observed in most completed clinical trials.There are still many issues to be resolved to promote the use of MSCs in the clinic in the future.In this review,we will examine the controversial role of MSCs in the pathogenesis and treatment of hepatic fibrosis/cirrhosis.We also investigated the clinical trials involving MSCs in liver cirrhosis,summarized the parameters that need to be standardized,and discussed how to promote the use of MSCs from a clinical perspective.

Mesenchymal stromal cellsHepatic fibrosis/cirrhosisPathogenesisTreatmentClinical application

Xue Yang、Qing Li、Wenting Liu、Chen Zong、Lixin Wei、Yufang Shi、Zhipeng Han

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Department of Tumor Immunology and Gene Therapy Center,Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China

Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education,Eastern Hepatobiliary Surgery Hospital/National Center for Liver Cancer,Naval Medical University,Shanghai 200438,China

The Third Affiliated Hospital of Soochow University,Institutes for Translational Medicine,State Key Laboratory of Radiation Medicine and Protection,Key Laboratory

CAS Key Laboratory of Tissue Microenvironment and Tumor,Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China

The Third Affiliated Hospital of Soochow University,Institutes for Translational Medicine,State Key Laboratory of Radiation Medicine and Protection,Key Laboratory of Stem Cells and Medical Biomaterials of Jiangsu Province,Medical College of Soochow University,Soochow University,Suzhou 215000,China

Department of Experimental Medicine,TOR,University of Rome Tor Vergata,00133 Rome,Italy

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National Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

2018YFA01075008217327681972599819300858207303282073037818722432022YFA0807300

2023

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子:0.731
ISSN:1672-7681
年,卷(期):2023.20(6)
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