首页|IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
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Defective interleukin-6(IL-6)signaling has been associated with Th2 bias and elevated IgE levels.However,the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown.Using a model of house dust mite(HDM)-induced Th2 cell differentiation and allergic airway inflammation,we showed that IL-6 signaling in allergen-specific T cells was required to prevent Th2 cell differentiation and the subsequent IgE response and allergic inflammation.Th2 cell lineage commitment required strong sustained IL-2 signaling.We found that IL-6 turned off IL-2 signaling during early T-cell activation and thus inhibited Th2 priming.Mechanistically,IL-6-driven inhibition of IL-2 signaling in responding T cells was mediated by upregulation of Suppressor Of Cytokine Signaling 3(SOCS3).This mechanism could be mimicked by pharmacological Janus Kinase-1(JAK1)inhibition.Collectively,our results identify an unrecognized mechanism that prevents the development of unwanted Th2 cell responses and associated diseases and outline potential preventive interventions.
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