New genetic and epigenetic insights into the chemokine system:the latest discoveries aiding progression toward precision medicine

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外文摘要：Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results from analyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.

外文关键词：

ChemokineChemokine receptorMigrationHomeostasisGeneticsEpigenetics

作者：

Hanli Xu、Shuye Lin、Ziyun Zhou、Duoduo Li、Xiting Zhang、Muhan Yu、Ruoyi Zhao、Yiheng Wang、Junru Qian、Xinyi Li、Bohan Li、Chuhan Wei、Keqiang Chen、Teizo Yoshimura、Ji Ming Wang、Jiaqiang Huang

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作者单位：

College of Life Sciences and Bioengineering,School of Physical Science and Engineering,Beijing Jiaotong University,3 ShangyuanCun,Haidian District,100044 Beijing,P.R.China

Cancer Research Center,Beijing Chest Hospital,Capital Medical University,Beijing Tuberculosis and Thoracic Tumor Institute,101149 Beijing,China

Laboratory of Cancer Innovation,Center for Cancer Research,National Cancer Institute at Frederick,Frederick,MD 21702,USA

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaBeijing Jiaotong University undergraduate innovation and entrepreneurship training projectBeijing Jiaotong University undergraduate innovation and entrepreneurship training projectBeijing Jiaotong University undergraduate innovation and entrepreneurship training projectBeijing Jiaotong University undergraduate innovation and entrepreneurship training projectBeijing Jiaotong University undergraduate innovation and entrepreneurship training projectR&D Program of Beijing Municipal Education CommissionBeijing Hospitals Authority Youth ProgrammeFederal funds from the National Cancer Institute,National Institutes of HealthIntramural Research Programs of the NCI,CCR,and NIH

项目编号：

8187202132200462220171097220171072220171037220171088220171104KM202110025004QML20231602HHSN261200800001E

出版年：

2023

DOI：

10.1038/s41423-023-01032-x

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(7)

参考文献量355