Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells

扫码查看

原文链接

万方数据

外文摘要：Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells.Inducible T-cell costimulator(ICOS)is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid tissues.However,the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains unclear.Here,we found that ICOS expression on human ILC3s was correlated with the activated state of ILC3s.ICOS costimulation enhanced the survival,proliferation,and capacity of ILC3s to produce cytokines(IL-22,IL-17A,IFN-γ,TNF,and GM-CSF).Via synergistic effects of ICOS and CD40 signaling,B cells promoted ILC3 functions,and ILC3-induced T-cell-independent B-cell IgA and IgM secretion primarily required CD40 signaling.Hence,ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells.

外文关键词：

Innate lymphoid cellB cellTonsilICOSCostimulatory molecule

作者：

Xinping Lv、Shan Zhu、Jing Wu、Jinfeng Shi、Qiuyu Wei、Tete Li、Ning Yang、Chunyan Liu、Lingli Qi、Guoxia Zang、Hang Cheng、Zhiguang Yang、Chengyan Jin、Yusheng Wang、Jiuwei Cui、Hideki Ueno、Yong-Jun Liu、Jingtao Chen

展开 >

作者单位：

Cancer Center,First Hospital of Jilin University,Changchun,Jilin 130021,China

Laboratory for Tumor Immunology,First Hospital of Jilin University,Changchun,Jilin 130061,China

Department of Otolaryngology Head and Neck Surgery,First Hospital of Jilin University,Changchun,Jilin 130021,China

Department of Translational Medicine,Changchun GeneScience Pharmaceuticals Co.,Ltd.,Changchun,Jilin 130012,China

Department of Gynecology,First Hospital of Jilin University,Changchun,Jilin 130021,China

Department of Pediatric Gastroenterology,First Hospital of Jilin University,Changchun,Jilin 130021,China

Department of Pediatrics,First Hospital of Jilin University,Changchun,Jilin 130021,China

Department of Thoracic Surgery,First Hospital of Jilin University,Changchun,Jilin 130021,China

Department of Thoracic Surgery,Second Hospital of Jilin University,Changchun,Jilin 130041,China

Department of Immunology,Graduate School of Medicine,Kyoto University,Kyoto,Japan

ASHBi Institute for the Advanced Study of Human Biology,Kyoto University,Kyoto,Japan

展开 >

基金：

National Key Research and Development ProgramScience and Technology Development Program of Jilin ProvinceScience and Technology Development Program of Jilin ProvinceNorman Bethune Program of Jilin University

项目编号：

2021YFF070480020210402009GHYDZJ202201ZYTS0982022B34

出版年：

2023

DOI：

10.1038/s41423-023-01041-w

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(7)

参考文献量51