首页|Roles of macrophages in tumor development:a spatiotemporal perspective

Roles of macrophages in tumor development:a spatiotemporal perspective

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Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment(TME).In both primary tumors and metastases,such tumor-associated macrophages(TAMs)seem to support tumor development.While we know that TAMs are the dominant immune cells in the TME,their vast heterogeneity and associated functions are only just being unraveled.In this review,we outline the various known TAM populations found thus far and delineate their specialized roles associated with the main stages of cancer progression.We discuss how macrophages may prime the premetastatic niche to enable the growth of a metastasis and then how subsequent metastasis-associated macrophages can support secondary tumor growth.Finally,we speculate on the challenges that remain to be overcome in TAM research.

MacrophagesTumor associated macrophagesTumor microenvironmentMetastasis

Mathilde Bied、William W.Ho、Florent Ginhoux、Camille Blériot

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Institut Gustave Roussy,INSERM U1015,Villejuif,France

Singapore Immunology Network(SIgN),Agency for Science,Technology and Research(A∗STAR),Singapore,Singapore

Shanghai Institute of Immunology,Shanghai JiaoTong University School of Medicine,Shanghai,China

Translational Immunology Institute,SingHealth Duke-NUS,Singapore,Singapore

Institut Necker des Enfants Malades,INSERM,CNRS,Université Paris Cité,Paris,France

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2023

10.1038/s41423-023-01061-6

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.731
ISSN：1672-7681
年,卷(期)：2023.20(9)
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