首页|Regulation of CD8+ T memory and exhaustion by the mTOR signals

Regulation of CD8+ T memory and exhaustion by the mTOR signals

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CD8+ T cells are the key executioners of the adaptive immune arm,which mediates antitumor and antiviral immunity.Naïve CD8+ T cells develop in the thymus and are quickly activated in the periphery after encountering a cognate antigen,which induces these cells to proliferate and differentiate into effector cells that fight the initial infection.Simultaneously,a fraction of these cells become long-lived memory CD8+ T cells that combat future infections.Notably,the generation and maintenance of memory cells is profoundly affected by various in vivo conditions,such as the mode of primary activation(e.g.,acute vs.chronic immunization)or fluctuations in host metabolic,inflammatory,or aging factors.Therefore,many T cells may be lost or become exhausted and no longer functional.Complicated intracellular signaling pathways,transcription factors,epigenetic modifications,and metabolic processes are involved in this process.Therefore,understanding the cellular and molecular basis for the generation and fate of memory and exhausted CD8+ cells is central for harnessing cellular immunity.In this review,we focus on mammalian target of rapamycin(mTOR),particularly signaling mediated by mTOR complex(mTORC)2 in memory and exhausted CD8+ T cells at the molecular level.

mTORSin1CD8+ T cellT-cell memoryT-cell exhaustion

Yao Chen、Ziyang Xu、Hongxiang Sun、Xinxing Ouyang、Yuhen Han、Haihui Yu、Ningbo Wu、Yiting Xie、Bing Su

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Shanghai Institute of Immunology,Department of Immunology and Microbiology,and The Ministry of Education Key Laboratory of Cell Death and Differentiation,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Department of Tumor Biology,Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Center for Immune-Related Diseases at Shanghai Institute of Immunology,Department of Gastroenterology,Ruijin Hospital,Shanghai Jiao Tong University School of Medici

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key R&D Program of ChinaShanghai Science and Technology CommissionShanghai Science and Technology CommissionShanghai Science and Technology CommissionShanghai Science and Technology CommissionShanghai Science and Technology CommissionShanghai Frontiers Science Center of Cellular Homeostasis and Human DiseasesChina Postdoctoral Science FoundationChina Postdoctoral Science FoundationNurture projects for basic research of Shanghai Chest Hospitalfellowships from Shanghai Postdoctoral Excellence ProgramChina International Postdoctoral Exchange Fellowship Program(Talent-Introduction Program)Zhi-Yuan Endowed fund from Shanghai Jiao Tong University

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2023

10.1038/s41423-023-01064-3

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.731
ISSN：1672-7681
年,卷(期)：2023.20(9)
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