Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

扫码查看

原文链接

万方数据

外文摘要：The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults.Disruption of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses,whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections,but also influence cancer development and progression.Glycans have emerged as essential components of homeostatic circuits,acting as fine-tuners of immunological responses and potential molecular targets for manipulation of immune tolerance and activation in a wide range of pathologic settings.Cell surface glycans,present in cells,tissues and the extracellular matrix,have been proposed to serve as"self-associated molecular patterns"that store structurally relevant biological data.The responsibility of deciphering this information relies on different families of glycan-binding proteins(including galectins,siglecs and C-type lectins)which,upon recognition of specific carbohydrate structures,can recalibrate the magnitude,nature and fate of immune responses.This process is tightly regulated by the diversity of glycan structures and the establishment of multivalent interactions on cell surface receptors and the extracellular matrix.Here we review the spatiotemporal regulation of selected glycan-modifying processes including mannosylation,complex N-glycan branching,core 2 O-glycan elongation,LacNAc extension,as well as terminal sialylation and fucosylation.Moreover,we illustrate examples that highlight the contribution of these processes to the control of immune responses and their integration with canonical tolerogenic pathways.Finally,we discuss the power of glycans and glycan-binding proteins as a source of immunomodulatory signals that could be leveraged for the treatment of autoimmune inflammation and chronic infection.

外文关键词：

Immune responseInflammationInfectionGlycansGlycosylationGlycan-binding proteins

作者：

Salomé S.Pinho、Inês Alves、Joana Gaifem、Gabriel A.Rabinovich

展开 >

作者单位：

i3S-Institute for Research and Innovation in Health,University of Porto,4200-135 Porto,Portugal

ICBAS-School of Medicine and Biomedical Sciences,University of Porto,4050-313 Porto,Portugal

Faculty of Medicine,University of Porto,4200-319 Porto,Portugal

Laboratorio de Glicomedicina,Instituto de Biología y Medicina Experimental(IBYME),Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET),C1428 Ciudad de Buenos Aires,Argentina

Facultad de Ciencias Exactas y Naturales,Universidad de Buenos Aires,C1428 Ciudad de Buenos Aires,Argentina

展开 >

基金：

European Union or European Health and Digital Executive Agency2022 LRA Lupus Innovation AwardEuropean Crohn's and Colitis Organisation(ECCO)Pioneer Award 2021US Department of DefenseUS Army Medical Research Acquisition ActivityFY18 Peer Reviewed Medical Research Program Investigator-Initiated Research AwardPortuguese Foundation for Science and Technology-FCTFCT for fundingESCMIDFCTArgentinean Agency for Promotion of Science,Technology and InnovationArgentinean Agency for Promotion of Science,Technology and InnovationArgentinean Agency for Promotion of Science,Technology and Innovation

项目编号：

award number W81XWH1920053EXPL/MED-ONC/0496/20212022.00337.CEECINDESCMID Research Grant 20222020.00088.CEECINDPICT 2017-0494PICT-FBB 620PICT 2020-01552

出版年：

2023

DOI：

10.1038/s41423-023-01074-1

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(10)

参考文献量168