首页|A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells
A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells
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SATB1(Special A-T rich Binding protein 1)is a cell type-specific factor that regulates the genetic network in developing T cells and neurons.In T cells,SATB1 is required for lineage commitment,VDJ recombination,development and maturation.Considering that its expression varies during B-cell differentiation,the involvement of SATB1 needs to be clarified in this lineage.Using a KO mouse model in which SATB1 was deleted from the pro-B-cell stage,we examined the consequences of SATB1 deletion in naive and activated B-cell subsets.Our model indicates first,unlike its essential function in T cells,that SATB1 is dispensable for B-cell development and the establishment of a broad IgH repertoire.Second,we show that SATB1 exhibits an ambivalent function in mature B cells,acting sequentially as a positive and negative regulator of Ig gene transcription in naive and activated cells,respectively.Third,our study indicates that the negative regulatory function of SATB1 in B cells extends to the germinal center response,in which this factor limits somatic hypermutation of Ig genes.
B cellsNuclear factorAmbivalentSomatic hypermutation
Laboratoire Contrôle de la Réponse Immune B et des Lymphoproliférations(CRIBL),Université de Limoges,CNRS Unité Mixte de Recherche 7276,Inserm Unité 1262,Limoges,France
Laboratoire Suivi des Thérapies Innovantes,Institut de Génétique Humaine,UMR 9002 CNRS-UM,Montpellier,France
Centre Hospitalier Universitaire Dupuytren,Service d'Immunopathologie,Limoges,France
Centre Hospitalier Universitaire de Limoges,Centre National de I'Amylose AL et Autres Maladies par Dépôt d'Immunoglobulines Monoclonales,Limoges,France
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BISCEm unitBISCEm unitBISCEm unitBISCEm unitFrench Ministère de I'Enseignement Supérieur,de la Recherche et del'Innovation and the Fonds Européen de Développement RégioLa Ligue Contre le CancerLa Ligue Contre le CancerFondation ARC pour la recherche sur le cancerInstitut CARNOT CALYM,INCa-Cancérop?le GSO Emergence(to EP)
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