The role of cellular and molecular neuroimmune crosstalk in gut immunity

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外文摘要：The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system.These two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and inflammation.The brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic neurons.Neurons regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain axis.This neuroimmune crosstalk is critical for gut homeostatic maintenance and disease resolution.In this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal immunity.We will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and inflammation.We also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

外文关键词：

NeuroimmunologyNeuroimmuneHost defenseGutSensory

作者：

Daping Yang、Nicole Almanzar、Isaac M.Chiu

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作者单位：

Department of Immunology,Harvard Medical School,Boston,MA 02115,USA

基金：

NIH grantsNIH grantsKenneth Rainin FoundationBurroughs Wellcome FundFood Allergy Science InitiativeChan-Zuckerberg InitiativeFairbairn Lyme InitiativeDrako Family FoundationJackson-Wijaya Research Fund

项目编号：

R01 DK127257R01 AI168005

出版年：

2023

DOI：

10.1038/s41423-023-01054-5

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(11)

参考文献量87