Brain macrophage development,diversity and dysregulation in health and disease

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外文摘要：Brain macrophages include microglia in the parenchyma,border-associated macrophages in the meningeal-choroid plexus-perivascular space,and monocyte-derived macrophages that infiltrate the brain under various disease conditions.The vast heterogeneity of these cells has been elucidated over the last decade using revolutionary multiomics technologies.As such,we can now start to define these various macrophage populations according to their ontogeny and their diverse functional programs during brain development,homeostasis and disease pathogenesis.In this review,we first outline the critical roles played by brain macrophages during development and healthy aging.We then discuss how brain macrophages might undergo reprogramming and contribute to neurodegenerative disorders,autoimmune diseases,and glioma.Finally,we speculate about the most recent and ongoing discoveries that are prompting translational attempts to leverage brain macrophages as prognostic markers or therapeutic targets for diseases that affect the brain.

外文关键词：

MicrogliaMacrophagesMeningesBrainInflammation

作者：

Aymeric Silvin、Jiawen Qian、Florent Ginhoux

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作者单位：

INSERM U1015,Gustave Roussy Cancer Campus,Villejuif 94800,France

Shanghai Institute of Immunology,Department of Immunology and Microbiology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Singapore Immunology Network,Agency for Science,Technology and Research,Singapore 138648,Republic of Singapore

Translational Immunology Institute,SingHealth Duke-NUS Academic Medical Centre,Singapore 169856,Singapore

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出版年：

2023

DOI：

10.1038/s41423-023-01053-6

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(11)

参考文献量163