首页|FBXO38 regulates macrophage polarization to control the development of cancer and colitis

FBXO38 regulates macrophage polarization to control the development of cancer and colitis

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Macrophages are highly plastic cells that differentially regulate multiple pathological conditions,including cancer and autoimmune diseases.In response to various stimuli,macrophages activate different intrinsic signaling pathways and polarize into distinct macrophage subsets.We aimed to identify key new effectors that could control macrophage polarization and impact the development of cancer or colitis.Following treatment with the supernatants of tumor cells,macrophages showed an upregulation in Fbxo38 expression.Subsequently,we further identified that FBXO38 promotes macrophage immunosuppressive function by upregulating the expression of M2-like genes via MAPK and IRF4 signaling without affecting M1-like macrophage polarization.Deletion of Fbxo38 in macrophages was found to block tumor development and protect against DSS-induced colitis.Considering the distinct regulation of tumor development by FBXO38 in T cells and macrophages,we suggest that a comprehensive understanding of FBXO38 function in different cell types is critical for its further translational usage.

FBXO38Macrophage polarizationTumor progressionColitis

Xin Zheng、Qi Jiang、Mingshun Han、Fenfen Ye、Mingchang Wang、Ying Qiu、Jialu Wang、Minxia Gao、Fajian Hou、Hongyan Wang

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School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China

Hangzhou Institute for Advanced Study and Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,UniversityNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaMinistry of Science and Technology of ChinaScience and Technology Commission of Shanghai MunicipalityScience and Technology Commission of Shanghai MunicipalityChina Postdoctoral Science Foundation

818250113222100281930038823031542018YFA080070222JC1403001HS2021SHZX0012022M723141

2023

10.1038/s41423-023-01081-2

中国免疫学杂志(英文版)
中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.731
ISSN：1672-7681
年,卷(期)：2023.20(11)
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