Mitochondrial DNA-triggered innate immune response:mechanisms and diseases

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外文摘要：Various cellular stress conditions trigger mitochondrial DNA(mtDNA)release from mitochondria into the cytosol.The released mtDNA is sensed by the cGAS-MITA/STING pathway,resulting in the induced expression of type Ⅰ interferon and other effector genes.These processes contribute to the innate immune response to viral infection and other stress factors.The deregulation of these processes causes autoimmune diseases,inflammatory metabolic disorders and cancer.Therefore,the cGAS-MITA/STING pathway is a potential target for intervention in infectious,inflammatory and autoimmune diseases as well as cancer.In this review,we focus on the mechanisms underlying the mtDNA-triggered activation of the cGAS-MITA/STING pathway,the effects of the pathway under various physiological and pathological conditions,and advances in the development of drugs that target cGAS and MITA/STING.

外文关键词：

MitostressVirusInnate immunityDiseaseMITA/STING

作者：

Ming-Ming Hu、Hong-Bing Shu

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作者单位：

Department of Infectious Diseases,Medical Research Institute,Zhongnan Hospital of Wuhan University,Frontier Science Center for Immunology and Metabolism,Taikang Center for Life and Medical Sciences,College of Life Sciences,Wuhan University,Research Unit of Innate Immune and Inflammatory Diseases,Chinese Academy of Medical Sciences,Wuhan 430072,China

基金：

State Key R&D Program of ChinaFundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaCAMS Innovation Fund for Medical SciencesTranslational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University

项目编号：

2022YFA13049002042022dx000332188101318300242019-I2M-5-071ZNJC202205

出版年：

2023

DOI：

10.1038/s41423-023-01086-x

中国免疫学杂志(英文版)

中国免疫学会

中国免疫学杂志(英文版)

CSTPCDCSCDSCI

影响因子：0.731

ISSN：1672-7681

年,卷(期)：2023.20(12)

参考文献量205