以工业大麻花叶为原料,利用高效液相色谱(HPLC)和热重分析仪(TGA)对大麻二酚酸(CBDA)的脱羧反应过程进行表征,分析CBDA及其脱羧产物大麻二酚(CBD)在不同温度(50～145℃)和反应时间(4～180 min)的含量变化,并开展脱羧反应动力学分析.结果表明,CBDA脱羧反应遵循一级动力学,初步推测最佳脱羧温度区间为95～125℃,加热时间50～70 min.
The Thermal Decarboxylation Reaction Kinetics of Cannabidiolic Acid
The flowers and leaves of industrial hemp were used as raw material to investigate the de-carboxylation reaction process of cannabidiolic acid(CBDA)by using high performance liquid chroma-tography(HPLC)and thermal gravimetric analyzer(TGA).The content changes of CBDA and its decar-boxylation product cannabidiol(CBD)at different temperatures(50～145℃)and reaction time(5～180 min)were analyzed.The kinetics of this reaction was also studied.The results show that the CBDA decarboxylation reaction follows the first-order kinetics.The optimum decarboxylation temperature range and heating time were preliminarily assumed as 95～125℃and 50～70 min,respectively.
国家科技期刊平台
NSTL
万方数据
