Effects of Shuxuetong injection combined with Fibrinogenase injection in the treatment of patients with acute cerebral infarction
Objective:To investigate effects of Shuxuetong injection combined with Fibrinogenase injection in the treatment of patients with acute cerebral infarction(ACI).Methods:The clinical data of 98 patients with ACI admitted to this hospital from January 2022 to January 2023 were retrospectively analyzed.According to different treatment options,these patients were divided into observation group and control group,49 cases in each group.The control group was treated with Fibrinogenase injection,while the observation group was treated with Shuxuetong injection on the basis of the control group.The clinical efficacy,neurological function[National Institutes of Health stroke scale(NIHSS)],the self-care ability[Barthel index(BI)]score,the serum neurobiochemical indexes[central nervous system specific protein β(S100β),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF)]levels,the inflammatory factors[pentraxin 3(PTX3),soluble intercellular adhesion molecule-1(sICAM-1),macrophage colony stimulating factor(M-CSF)]levels,the incidence of adverse reactions,and re-infarction were compared between the two groups.Results:The total effective rate of the observation group was 91.84%(45/49),which was higher than 75.51%(37/49)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score and the serum levels of S100β,sICAM-1,M-CSF and PTX3 in the observation group were lower than those in the control group,the BI score and the serum levels of NGF and BDNF were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 6 months of follow-up,the incidence of re-infarction in the observation group was 2.04%(1/49),which was lower than 16.33%(8/49)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Shuxuetong injection combined with Fibrinogenase injection in the treatment of the ACI patients can improve the total effective rate of treatment,reduce the levels of inflammatory factors,reduce the neurological deficit,promote the neuron regeneration,improve the self-care ability of these patients,and reduce the incidence of re-infarction.Moreover,it is superior to single Fibrinogenase injection treatment.
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