首页|阿托伐他汀钙联合富马酸比索洛尔治疗心肌缺血患者的效果

阿托伐他汀钙联合富马酸比索洛尔治疗心肌缺血患者的效果

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目的:观察阿托伐他汀钙联合富马酸比索洛尔治疗心肌缺血患者的效果.方法:回顾性分析 2022 年 1 月至 2022 年 12 月本院收治的 88 例心肌缺血患者的临床资料,依据治疗方案的不同分为观察组和对照组各 44 例.对照组采用富马酸比索洛尔治疗,观察组在对照组基础上联合阿托伐他汀钙治疗,比较两组患者心功能指标、炎性指标和血流动力学指标水平,以及治疗期间不良反应发生率.结果:治疗后,观察组左心室射血分数高于对照组,左心室舒张末期内径、左心室收缩末期内径均小于对照组,血清白细胞介素-6、白细胞介素-10 和超敏C反应蛋白水平均低于对照组;观察组心率低于对照组,心搏出量、心输出量和心脏指数均高于对照组,差异有统计学意义(P<0.05).两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05).结论:阿托伐他汀钙联合富马酸比索洛尔治疗心肌缺血患者,可改善心功能和血流动力学指标水平,并降低炎性指标水平,效果优于富马酸比索洛尔单药治疗.
Clinical effects of Atorvastatin calcium combined with Bisoprolol fumarate in treatment of patients with myocardial ischemia
Objective:To observe clinical effects of Atorvastatin calcium combined with Bisoprolol fumarate in treatment of patients with myocardial ischemia.Methods:The clinical data of 88 patients with myocardial ischemia admitted to this hospital from January 2022 to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,44 cases in each group.The control group was treated with Bisoprolol fumarate,while the observation group was treated with Atorvastatin calcium on the basis of the control group.The levels of cardiac function indexes,inflammatory indexes and hemodynamic indexes,and the incidence of adverse reactions during treatment were compared between the two groups.Results:After the treatment,the left ventricular ejection fraction in the observation group was higher than that in the control group;the levels of left ventricular end-diastolic diameter,left ventricular end-systolic diameter,interleukin-6,interleukin-10 and high-sensitivity C-reactive protein were lower than those in the control group;the heart rate of the observation group was lower than that of the control group;the levels of cardiac output,cardiac output and cardiac index were higher than those of the control group;and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Atorvastatin calcium combined with Bisoprolol fumarate in the treatment of the patients with myocardial ischemia can improve the cardiac function and the hemodynamic index levels,and reduce the levels of inflammatory indexes.Moreover,it is superior to single Bisoprolol fumarate treatment.

Myocardial ischemiaBisoprolol fumarateAtorvastatin calciumCardiac functionInflammationHemodynamicsAdverse reaction

许冲、刘岢

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平顶山市中医医院药学部,河南 平顶山 467000

心肌缺血 富马酸比索洛尔 阿托伐他汀钙 心功能 炎症 血流动力学 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(1)
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